Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring

摘要: BACKGROUND Prenatal exposures to endocrine-disrupting chemicals (EDCs) are suspected risk factors in the etiology of hypospadias. The aim this case-control study was test hypothesis an association between maternal environmental EDCs and hypospadias offspring. METHODS Detailed questionnaire data on occupational dietary perinatal period were collected from 80 mothers with hypospadiac infants healthy controls within 24 months childbirth. Maternal exposure selected also ascertained by measuring concentration dichlorodiphenyldichloroethylene, hexachlorobenzene, several polychlorinated biphenyl congeners serum primiparous 37 cases 21 controls. RESULTS The bear infant associated evaluated a job-exposure matrix: jobs one class (odds ratios [OR]crude, 2.83; 95% confidence intervals [CI], 1.32–6.07; ORadjusted, 2.44; CI, 1.06–5.61) more than group (ORcrude, 4.27; 1.43–12.78; 4.11; 95%CI, 1.34–12.59). Increase found among consuming diet rich fish or shellfish 3.41; 1.42–8.23; 2.73; 1.09–6.82). Serum hexachlorobenzene above median all subjects significantly (ORadjusted, 5.50; 1.24–24.31). CONCLUSIONS This study, although based limited number cases, for first time provides evidence EDCs, particular elevated plasma concentration, development offspring. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.