CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation

摘要: Human NK cells can be divided into CD56dimCD16+ killer Ig-like receptors (KIR)+/− and CD56brightCD16− KIR− subsets that have been characterized extensively regarding their different functions, phenotype, tissue localization. Nonetheless, the developmental relationship between these two cell remains controversial. We report that, upon cytokine activation, peripheral blood (PB)-CD56bright mainly gain signature of CD56dim cells. Remarkably, KIR induced not only on CD56bright, but also cells, expression correlates with lower proliferative response. In addition, we demonstrate for first time PB-CD56dim display shorter telomeres than PB- lymph node (LN)-derived CD56bright Along this line, although human collected from nonreactive LN almost no CD16 expression, derived highly reactive LN, efferent lymph, PB express significant amounts CD16, implying could acquire molecules in during inflammation then circulate through as KIR+CD16+ Altogether, our results suggest CD56dimCD16+KIR+/− correspond to sequential steps differentiation support hypothesis secondary lymphoid organs sites final maturation self-tolerance acquisition immune reaction.