Toxicogenomics applied to predictive and exploratory toxicology for the safety assessment of new chemical entities: a long road with deep potholes.

摘要: Toxicology is the perturbation of metabolism by external factors such as xenobiotics, environmental or drugs. As such, toxicology covers a broad range fields from studies whole organism responses to minute biochemical events. Mechanistic toxicogenomics an attempt harness genomic tools understand physiological basis for toxic event based on analysis transcriptional, translational metabolomic profiles. These are complicated non-toxic adaptive in transcript, protein metabolite expression levels that have be distinguished those proximally related event. Substantial progress has been made identification biomarkers and establishment screens derived studies. The ultimate goal, course, predictive toxicogenomics, which infer likelihood occurrence with exposure new agent upon comparative large databases gene, data. Gene currently limited fact measurable phenotypes generally precede at best coincide earliest observable changes transcriptional Unfortunately, technical difficulties. Metabonomics-based databases, would probably highest value, turn inability perform high dose humans. This chapter will conclude reviewing elements apply specifically development anti-infectives potential accuratelymodelling toxicity future