Notch: a key regulator of tumor angiogenesis and metastasis.

摘要: The Notch signaling pathway is critical for many developmental processes including physiologic angiogenesis. also implicated in having a key role tumor Preclinical and clinical experience with anti-angiogenic strategies indicates that they may be limited by resistance recurrence, which has led to the search alternative angiogenic treatment strategies. Significant progress been made shedding light on complex mechanisms can influence growth disrupting vasculature an array of models (Ridgway et al., 2006). These results have consideration as attractive target block angiogenesis inhibit growth. However, studies inhibition different uncovered similarly variable results, some unexpected adverse effects. ability function context-dependent manner determinant cell fate, suppressor, oncogene partially explain complexity interpreted inhibitors preclinical studies. In addition, play important metastasis via its direct effects modulation epithelial-mesenchymal transition cells. Here we present current understanding angiogenesis, discuss recent work metastatic progression.