Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

摘要: The effect of a stimulus to the brain depends not only on parameters but also dynamics activity at time stimulation. combination electroencephalography (EEG) and transcranial magnetic stimulation (TMS) in real-time state-dependent system allows study relations activity, cortical excitability, plasticity induction. Here, we demonstrate newly developed method synchronize timing with phase ongoing EEG oscillations using data analysis system. This EEG-triggered TMS human motor cortex, when is synchronized surface negative peak sensorimotor µ-alpha (8-14 Hz) rhythm, has shown differential corticospinal excitability effects. utilization this suggests that information about instantaneous state can be used for efficacious Additionally, approach enables personalized EEG-synchronized which may lead development more effective therapeutic protocols.