TRPC6-mediated ERK1/2 Activation Regulates Neuronal Excitability via Subcellular Kv4.3 Localization in the Rat Hippocampus
作者： Ji-Eun Kim , Jin-Young Park , Tae-Cheon Kang
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摘要: Recently, we have reported that transient receptor potential channel-6 (TRPC6) plays an important role in the regulation of neuronal excitability and synchronization spiking activity dentate granule cells (DGC). However, underlying mechanisms TRPC6 these phenomena been still unclear. In present study, investigated subcellular localization Kv4.3 its relevance to rat hippocampus. knockdown increased inhibitory transmission DGC CA1 neurons response a paired-pulse stimulus. impaired γ-aminobutyric acid (GABA)ergic inhibition hippocampus during after high-frequency stimulation (HFS). reduced clusters membrane fractions dendritic on GABAergic interneurons. also decreased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation efficacy 4-aminopyridine (4-AP) excitability. An ERK1/2 inhibitor generated multiple population spikes stimulus, concomitant with translocation. A activator (hyperforin) reversed effects TRPC knockdown, except inhibition. These findings provide valuable clues indicating TRPC6-mediated activation may regulate interneurons, which is cause-effect relationship between seizure susceptibility.
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Frank R Sharp, Midori Tomitaka, Myriam Bernaudin, Schinichiro Tomitaka, Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends in Neurosciences. ,vol. 24, pp. 330- 334 ,(2001) , 10.1016/S0166-2236(00)01817-8
Kim Lawson, Potassium channel openers as potential therapeutic weapons in ion channel disease Kidney International. ,vol. 57, pp. 838- 845 ,(2000) , 10.1046/J.1523-1755.2000.00923.X
Henry H. Jerng, Paul J. Pfaffinger, Manuel Covarrubias, Molecular physiology and modulation of somatodendritic A-type potassium channels. Molecular and Cellular Neuroscience. ,vol. 27, pp. 343- 369 ,(2004) , 10.1016/J.MCN.2004.06.011
Hsin-Yi Huang, Jen-Kun Cheng, Yang-Hsin Shih, Pei-Hsuan Chen, Chin-Lin Wang, Meei-Ling Tsaur, Expression of A‐type K+ channel α subunits Kv4.2 and Kv4.3 in rat spinal lamina II excitatory interneurons and colocalization with pain‐modulating molecules European Journal of Neuroscience. ,vol. 22, pp. 1149- 1157 ,(2005) , 10.1111/J.1460-9568.2005.04283.X
Sang-Kyu Lee, Ji-Eun Kim, Yeon-Joo Kim, Min-Ju Kim, Tae-Cheon Kang, Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus Neuroscience Research. ,vol. 85, pp. 39- 50 ,(2014) , 10.1016/J.NEURES.2014.05.006
Hongyu Li, Junbo Huang, Wanlu Du, Caixia Jia, Hailan Yao, Yizheng Wang, TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity Journal of Neurochemistry. ,vol. 123, pp. 1010- 1018 ,(2012) , 10.1111/JNC.12045
Raúl Setién, Aintzane Alday, Cristina Diaz-Asensio, Janire Urrutia, Mónica Gallego, Oscar Casis, Mechanisms Responsible for the Trophic Effect of Beta-Adrenoceptors on the I to Current Density in Type 1 Diabetic Rat Cardiomyocytes Cellular Physiology and Biochemistry. ,vol. 31, pp. 25- 36 ,(2013) , 10.1159/000343346
M. L. Bourdeau, F. Morin, C. E. Laurent, M. Azzi, J.-C. Lacaille, Kv4.3-Mediated A-Type K+ Currents Underlie Rhythmic Activity in Hippocampal Interneurons The Journal of Neuroscience. ,vol. 27, pp. 1942- 1953 ,(2007) , 10.1523/JNEUROSCI.3208-06.2007
C. Elgueta, J. Kohler, M. Bartos, Persistent Discharges in Dentate Gyrus Perisoma-Inhibiting Interneurons Require Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Activation The Journal of Neuroscience. ,vol. 35, pp. 4131- 4139 ,(2015) , 10.1523/JNEUROSCI.3671-14.2015
Daniela Merlo, Pierangelo Cifelli, Simona Cicconi, Virginia Tancredi, Massimo Avoli, 4-Aminopyridine-induced epileptogenesis depends on activation of mitogen-activated protein kinase ERK Journal of Neurochemistry. ,vol. 89, pp. 654- 659 ,(2004) , 10.1111/J.1471-4159.2004.02382.X