The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin

摘要: To overcome the problems associated with conventional liposomes in transdermal drug delivery like limited penetration ability and poor stability, this article we report a new generation of cell penetrating peptide polyarginine containing nano-liposomes conjugated carbon dots. The newly synthesized, cost-effective liposomic precursors were used for fabrication liposomes. resulting have bilayer structure that much smaller size, higher high ability. show stability at room temperature three months without any change size or encapsulation efficiency. incorporation dots also opens up their application fluorescence imaging studies, which is very well supported by microscopic analysis liposome skin penetration. as-prepared do not cytotoxicity MCF-7 cells, even concentrations; however, when loaded are applied, they can kill cancer cells rate. synthesized potential to be as an efficient, stable, biocompatible nanocarrier delivery.