Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa.

摘要: While antibiotic resistance in bacteria is rapidly increasing, the development of new antibiotics has decreased recent years. Antivirulence drugs disarming rather than killingpathogenshavebeenproposedtoalleviatetheproblem inherent to existing biocidal antibiotics. Here, we report a nontoxic biogenic nanomaterial as novel antivirulence agent combat bacterial infections caused by Pseudomonas aeruginosa. We synthesized, an environmen- tally benign fashion, tellurium nanorods (TeNRs) using metal-reducing bacterium Shewanella oneidensis, and found that TeNRs could effectively inhibit production pyoverdine, one most important virulence factors P. Our results suggest amyloidsandextracellular polysaccharides PelandPslarenot involved interactions between aeruginosa biogenicTeNRs,while flagellarmovementplaysanimportant role cell-TeNRs interaction. further showed (up 100mg/mL) did not exhibit cytotoxicity human bronchial epithelial cells murine macrophages. Thus, hold promise against