p53 mutation in human nasopharyngeal carcinomas.

摘要: Nasopharyngeal carcinoma (NPC) is the third most common cancer in southern provinces of China, but a rare other parts world. Epidemiological studies suggested multifactorial etiology NPC involving infection Epstein Barr virus (EBV), genetic predisposition, environmental factors, such as consumption salted fish, and unknown factors. p53 mutation event many forms human cancers its possible involvement pathogenesis has not been examined. The presence studied by sensitive PCR-SSCP analysis direct DNA sequencing