Sumatriptan, a selective 5-HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans

摘要: Sumatriptan, a 5-hydroxytryptamine1 (5-HT1) receptor agonist at enteric neuronal 5-HT receptors, causes relaxation of the gastric fundus and inhibition antral contractile activity. The present study examined effect sumatriptan on emptying solids liquids in humans. In eight healthy subjects rate for was measured using carbon-labeled glycine octanoic acid breath test after subcutaneous administration placebo or sumatriptan. Sumatriptan increased half-emptying time (P < 0.0005) induced prolonged lag phase all subjects. 0.005) 0.05) two studied by radioscintigraphy. Radioscintigraphy confirmed delayed phases conclusion, delays Moreover, induces liquids. mechanism which alters remains to be studied.