Polyarteritis nodosa reports to the vaccine adverse event reporting system (VAERS): implications for assessment of suspected vaccine-provoked vasculitis.

摘要: OBJECTIVE: To examine polyarteritis nodosa (PAN) reports to the Vaccine Adverse Event Reporting System (VAERS) as initial stage in investigating hypothesis that vaccination can very rarely cause PAN. METHODS: We reviewed PAN submitted from 1990 through 2001 using a causal inference framework evaluate consistency of reports9 clinical details with this hypothesis. also published literature relating hypothesized association9s biological plausibility. RESULTS: VAERS received 25 reports. Ten met our case definition for definite or possible and had no alternative etiology identified. Nine these 10 followed hepatitis B vaccine modal peak (4 cases) time symptom onset 2 weeks after vaccination. However, all potential triggering infections were not excluded, identification antigens specimens was attempted. Also, 14 European, 11 France. All 9 French known diagnosis date began during 1994-97, when autoimmune rheumatologic events following focus public concern CONCLUSION: While we identified some supportive evidence, overall, current adverse event do support link between Appropriate prospective evaluation future post-vaccination cases could add knowledge rigorous confirmation diagnosis, appropriate testing including polymerase chain reaction latent infection, an attempt antigen pathology such by immunohistochemical staining immune complex identification.