The PGC-1/ERR network and its role in precision oncology

摘要: Transcriptional regulators include a superfamily of nuclear proteins referred to as co-activators and co-repressors, both which are involved in controlling the functions several receptors (NRs). The Nuclear Receptor Signaling Atlas (NURSA) has cataloged composition NRs, co-regulators, ligands present human cell their effort been identified more than 600 potential molecules. Given importance co-regulators steroid, retinoid, thyroid hormone signaling networks, hypothesizing that NRs/co-regulators implicated wide range pathologies tempting. known peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1) key partner, estrogen-related (ERR), emerging pivotal transcriptional signatures regulate an extremely broad repertoire mitochondrial metabolic genes, making them very attractive drug targets for cancer. Several studies have provided increased understanding functional structural biology complexes. However, comprehensive work is needed create different avenues explore therapeutic NRs/co-activators precision oncology. Here, we discuss data associated with structure, function, molecular PGC-1/ERR network address how concepts evolving from these deepened our develop effective treatment strategies. We overview underscores new biological insights into improve cancer outcomes against resistance. Finally, exploiting technologies such single-particle cryo-electron microscopy (cryo-EM) high-resolution structure PGC-1/ERR, focusing on novel discovery