Identification of Prostaglandin Pathway in Dinoflagellates by Transcriptome Data Mining.
作者： Valeria Di Dato , Adrianna Ianora , Giovanna Romano
DOI: 10.3390/MD18020109
关键词:
摘要: Dinoflagellates, a major class of marine eukaryote microalgae composing the phytoplankton, are widely recognised as producers large variety toxic molecules, particularly neurotoxins, which can also act potent bioactive pharmacological mediators. In addition, similarly to other microalgae, they good polyunsaturated fatty acids (PUFAs), important precursors key molecules involved in cell physiology. Among PUFA derivatives prostaglandins (Pgs), physiological mediators several and pathological processes humans, used “biological” drugs. Their synthesis is very expensive because elevated number reaction steps required, thus search for new Pgs production methods great relevance. One possibility their extraction from microorganisms (e.g., diatoms), have been proved produce same humans. present study, we took advantage available transcriptomes dinoflagellates iMicrobe database biosynthetic pathway using bioinformatic approach. Here show that express nine Pg-metabolism related enzymes both reduction. Not all were expressed simultaneously species analysed expression was influenced by culturing conditions, especially salinity growth medium. These results confirm existence these unicellular than diatoms, suggesting broad diffusion conservation pathway, further strengthen importance living organisms.
mdpi.com
sci-hub.se 参考文章(34)
Da-Zhi Wang, Shu-Fei Zhang, Yong Zhang, Lin Lin, Paralytic shellfish toxin biosynthesis in cyanobacteria and dinoflagellates: A molecular overview. Journal of Proteomics. ,vol. 135, pp. 132- 140 ,(2016) , 10.1016/J.JPROT.2015.08.008
Valentin Stonik, Inna Stonik, Low-molecular-weight metabolites from diatoms: structures, biological roles and biosynthesis. Marine Drugs. ,vol. 13, pp. 3672- 3709 ,(2015) , 10.3390/MD13063672
Ana Mendes, Alberto Reis, Rita Vasconcelos, Pedro Guerra, Teresa Lopes da Silva, Crypthecodinium cohnii with emphasis on DHA production: a review Journal of Applied Phycology. ,vol. 21, pp. 199- 214 ,(2009) , 10.1007/S10811-008-9351-3
Hsin-Hsiung Tai, Charles Mark Ensor, Min Tong, Huiping Zhou, Fengxiang Yan, Prostaglandin catabolizing enzymes Prostaglandins & Other Lipid Mediators. ,vol. 68-69, pp. 483- 493 ,(2002) , 10.1016/S0090-6980(02)00050-3
Michail I. Gladyshev, Nadezhda N. Sushchik, Olesia N. Makhutova, Production of EPA and DHA in aquatic ecosystems and their transfer to the land Prostaglandins & Other Lipid Mediators. ,vol. 107, pp. 117- 126 ,(2013) , 10.1016/J.PROSTAGLANDINS.2013.03.002
Alexandra Andreou, Florian Brodhun, Ivo Feussner, Biosynthesis of oxylipins in non-mammals Progress in Lipid Research. ,vol. 48, pp. 148- 170 ,(2009) , 10.1016/J.PLIPRES.2009.02.002
Patrick J. Keeling, Fabien Burki, Heather M. Wilcox, Bassem Allam, Eric E. Allen, Linda A. Amaral-Zettler, E. Virginia Armbrust, John M. Archibald, Arvind K. Bharti, Callum J. Bell, Bank Beszteri, Kay D. Bidle, Connor T. Cameron, Lisa Campbell, David A. Caron, Rose Ann Cattolico, Jackie L. Collier, Kathryn Coyne, Simon K. Davy, Phillipe Deschamps, Sonya T. Dyhrman, Bente Edvardsen, Ruth D. Gates, Christopher J. Gobler, Spencer J. Greenwood, Stephanie M. Guida, Jennifer L. Jacobi, Kjetill S. Jakobsen, Erick R. James, Bethany Jenkins, Uwe John, Matthew D. Johnson, Andrew R. Juhl, Anja Kamp, Laura A. Katz, Ronald Kiene, Alexander Kudryavtsev, Brian S. Leander, Senjie Lin, Connie Lovejoy, Denis Lynn, Adrian Marchetti, George McManus, Aurora M. Nedelcu, Susanne Menden-Deuer, Cristina Miceli, Thomas Mock, Marina Montresor, Mary Ann Moran, Shauna Murray, Govind Nadathur, Satoshi Nagai, Peter B. Ngam, Brian Palenik, Jan Pawlowski, Giulio Petroni, Gwenael Piganeau, Matthew C. Posewitz, Karin Rengefors, Giovanna Romano, Mary E. Rumpho, Tatiana Rynearson, Kelly B. Schilling, Declan C. Schroeder, Alastair G. B. Simpson, Claudio H. Slamovits, David R. Smith, G. Jason Smith, Sarah R. Smith, Heidi M. Sosik, Peter Stief, Edward Theriot, Scott N. Twary, Pooja E. Umale, Daniel Vaulot, Boris Wawrik, Glen L. Wheeler, William H. Wilson, Yan Xu, Adriana Zingone, Alexandra Z. Worden, The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the Functional Diversity of Eukaryotic Life in the Oceans through Transcriptome Sequencing PLoS Biology. ,vol. 12, pp. e1001889- 6 ,(2014) , 10.1371/JOURNAL.PBIO.1001889
Nina Jaeckisch, Ines Yang, Sylke Wohlrab, Gernot Glöckner, Juergen Kroymann, Heiko Vogel, Allan Cembella, Uwe John, Comparative Genomic and Transcriptomic Characterization of the Toxigenic Marine Dinoflagellate Alexandrium ostenfeldii PLoS ONE. ,vol. 6, pp. e28012- ,(2011) , 10.1371/JOURNAL.PONE.0028012
Yoshiyuki Kawamoto, Yoshimasa Nakamura, Yuko Naito, Yasuyoshi Torii, Takeshi Kumagai, Toshihiko Osawa, Hajime Ohigashi, Kimihiko Satoh, Masayoshi Imagawa, Koji Uchida, Cyclopentenone Prostaglandins as Potential Inducers of Phase II Detoxification Enzymes 15-DEOXY-Δ12,14-PROSTAGLANDIN J2-INDUCED EXPRESSION OF GLUTATHIONE S-TRANSFERASES Journal of Biological Chemistry. ,vol. 275, pp. 11291- 11299 ,(2000) , 10.1074/JBC.275.15.11291
Emin Yilmaz, Biotechnological production of prostaglandin. Biotechnology Advances. ,vol. 19, pp. 387- 397 ,(2001) , 10.1016/S0734-9750(01)00072-6