A prospective randomised controlled trial of tamoxifen and cyproterone acetate in pancreatic carcinoma.
作者： JJ Keating , PJ Johnson , AMG Cochrane , BG Gazzard , N Krasner
DOI: 10.1038/BJC.1989.361
关键词:
摘要: In a prospective controlled clinical trial, 108 patients with pancreatic adenocarcinoma were randomly allocated to receive tamoxifen 20 mg b.d., cyproteron acetate 100 t.d.s. or no active treatment. The median survival of those receiving was longer than either the other two groups (5.25 compared 4.25 and 3 months, respectively) but this difference did not achieve statistical significance. Cox regression analysis 12 biochemical features showed that, for entire group patients, significantly in younger undergoing surgical bypass better initial performance status. However, even when adjustment made allow distribution these prognostic variables within three groups, still No side-effects attributable treatment observed.
nature.com
sci-hub.se 参考文章(13)
Nicola Medici, Ernesto Nola, Anna Maria Molinari, Giovanni Alfredo Puca, Antonella Petrillo, Vincenzo Sica, Alessandro Weisz, Maria Teresa Masucci, Rodolfo Bova, Enrico Contieri, Estradiol and progesterone receptors in malignant gastrointestinal tumors Cancer Research. ,vol. 44, pp. 4670- 4674 ,(1984)
T. W. Redding, A. V. Schally, Inhibition of growth of pancreatic carcinomas in animal models by analogs of hypothalamic hormones Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 248- 252 ,(1984) , 10.1073/PNAS.81.1.248
Birgir Gudjonsson, Elliot M. Livstone, Howard M. Spiro, Cancer of the pancreas. Diagnostic accuracy and survival statistics Cancer. ,vol. 42, pp. 2494- 2506 ,(1978) , 10.1002/1097-0142(197811)42:5<2494::AID-CNCR2820420554>3.0.CO;2-R
B Greenway, M J Iqbal, P J Johnson, R Williams, Oestrogen receptor proteins in malignant and fetal pancreas. BMJ. ,vol. 283, pp. 751- 753 ,(1981) , 10.1136/BMJ.283.6294.751
B. Greenway, D. Duke, Barbara Pym, M. J. Iqbal, P. J. Johnson, R. Williams, The control of human pancreatic adenocarcinoma xenografts in nude mice by hormone therapy British Journal of Surgery. ,vol. 69, pp. 595- 597 ,(2005) , 10.1002/BJS.1800691013
Stephen K. Carter, Robert L. Comis, The integration of chemotherapy into a combined modality approach for cancer treatment Cancer Treatment Reviews. ,vol. 2, pp. 193- 214 ,(1975) , 10.1016/S0305-7372(75)80003-X
David Gonzalez-Barcena, NormaE. Rangel-Garcia, PatriciaL. Perez-Sanchez, Cesar Gutierrez-Damperio, Fausto Garcia-Carrasco, AnaMaria Comaru-Schally, AndrewV. Schally, RESPONSE TO D-TRP-6-LH-RH IN ADVANCED ADENOCARCINOMA OF PANCREAS The Lancet. ,vol. 328, pp. 154- ,(1986) , 10.1016/S0140-6736(86)91961-6
Theve No, Carlström K, Pousette A, Adenocarcinoma of the pancreas--a hormone sensitive tumor? A preliminary report on Nolvadex treatment. Clinical Oncology. ,vol. 9, pp. 193- ,(1983)
Ogawa H, Aoki K, Cancer of the pancreas, international mortality trends. World health statistics quarterly. Rapport trimestriel de statistiques sanitaires mondiales. ,vol. 31, pp. 2- 27 ,(1978)
Kamp-Jensen M, Tønnesen K, Antiestrogen therapy in pancreatic carcinoma: a preliminary report. Ejso. ,vol. 12, pp. 69- 70 ,(1986)