Functional Polylactide-g-Paclitaxel―Poly(ethylene glycol) by Azide―Alkyne Click Chemistry
作者： Yun Yu , Jiong Zou , Lu Yu , Wei Ji , Yukun Li
DOI: 10.1021/MA2005102
关键词:
摘要: Functional polylactide-g-paclitaxel–poly(ethylene glycol), a novel graft polymer–drug conjugate (GPDC) with paclitaxel (PTXL) as the divalent agent to bridge between degradable polylactide (PLA)-based backbone and hydrophilic poly(ethylene glycol) (PEG) side chains, were prepared by copper-catalyzed azide–alkyne cycloaddition reaction of acetylene-functionalized (PLA) azide-functionalized PTXL–PEG conjugate. The PLA was ring-opening copolymerization (ROCP) LA monomer l-lactide (LA). multistep organic synthesis. well-controlled chemical structures GPDC its precursors verified 1H NMR GPC characterizations. DLS analysis indicated that molecules assembled in water form nanoparticles sizes 8–40 nm. buffer solutions (pH = 5.5 7.4) suggested occurrence multiple hydrolysis reactio...
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