Combating Mosquito-Borne Lymphatic Filariasis with Genomics Technologies: Enabling Novel Drug Discovery for Neglected Tropical Diseases

摘要: While the personalized medicine literature has hitherto focused on diseases in developed countries, little discussion materialized ways which genomics can importantly remedy highly prevalent developing countries. This paper aims to address this important lacuna biomedical literature— what we refer herein as ―developing world genomics‖ that needs recognition an emerging subspecialty of global medicine. We direct our attention neglected tropical (NTDs), a group high prevalence chronic parasitic and related infections affect world's poorest people. Lymphatic filariasis (LF) is mosquito-borne NTD caused by thread like lymphatic-dwelling nematode causes significant disability well loss productivity nations. The sustainability ongoing efforts for vector control chemotherapy are uncertain new drugs required absence adulticidal drug while some mainstay threatened with resistance. In paper, share synthesize research findings focussed Wolbachia, endosymbiont bacteria filarial parasites, itself promising target development or customized vaccines it contributes normal functioning parasites. analyze recent advances parasite Wolbachial highlight potential applications genomic technologies targeted discovery therapeutics vast burden public health. Comparative approaches should also be valuable exploring genetic changes involved resistance antifilarial understanding mechanisms human