Autochthonous and dormant Cryptococcus gattii infections in Europe

摘要: Until recently, Cryptococcus gattii infections occurred mainly in tropical and subtropical climate zones. However, during the past decade, C. humans animals Europe have increased. To determine whether were acquired from an autochthonous source or associated with travel, we used multilocus sequence typing to compare 100 isolates (57 40 human patients, 22 environment, 21 animals) 191 around world. Of 57 patient isolates, 47 (83%) obtained since 1995. Among 24 (60%) probably infection outside Europe; remaining 16 (40%) within Europe. Human Mediterranean clustered into a distinct genotype animal environmental isolates. These results indicate that reactivation of dormant can occur many years after infectious agent was elsewhere.