Fetal and Maternal Genes’ Influence on Gestational Age in a Quantitative Genetic Analysis of 244,000 Swedish Births

摘要: Although there is increasing evidence that genetic factors influence gestational age, it unclear to what extent this due fetal and/or maternal genes. In study, we apply a novel analytical model estimate and environmental contributions pregnancy history records obtained from 165,952 Swedish families consisting of offspring twins, full siblings, half-siblings (1987–2008). Results indicated explained 13.1% (95% confidence interval (CI): 6.8, 19.4) the variation in age at delivery, while accounted for 20.6% CI: 18.1, 23.2). The largest contribution differences timing birth were factors, which 10.1% 7.0, 13.2) was shared by births same mother, 56.2% 53.0, 59.4) specific. Similar models fit data dichotomized clinically meaningful thresholds (e.g., preterm birth) resulted less stable parameter estimates, but collective results supported homogeneous effects across range age. Since most birth, studies may benefit understanding specific effect genes context these yet-unidentified factors.