Capillary isoelectric focusing method development and validation for investigation of recombinant therapeutic monoclonal antibody.
作者： Dávid Suba , Zoltán Urbányi , András Salgó
DOI: 10.1016/J.JPBA.2015.04.037
关键词:
摘要: … Capillary isoelectric focusing (cIEF) is a powerful tool to characterize charge profile of the monoclonal antibodies, because different charge variants can be distinguished according to …
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sci-hub.se 参考文章(20)
S Fujii, T Nishiura, A Nishikawa, R Miura, N Taniguchi, Structural heterogeneity of sugar chains in immunoglobulin G. Conformation of immunoglobulin G molecule and substrate specificities of glycosyltransferases. Journal of Biological Chemistry. ,vol. 265, pp. 6009- 6018 ,(1990) , 10.1016/S0021-9258(19)39283-X
Junzi Cao, Wen Sun, Feifei Gong, Wanhui Liu, Charge profiling and stability testing of biosimilar by capillary isoelectric focusing. Electrophoresis. ,vol. 35, pp. 1461- 1468 ,(2014) , 10.1002/ELPS.201300471
T Taniguchi, A Shimizu, A Kobata, T Mizuochi, Structural and numerical variations of the carbohydrate moiety of immunoglobulin G. Journal of Immunology. ,vol. 129, pp. 2016- 2020 ,(1982)
Xiaoping Z. He, Amy H. Que, Jim J. Mo, Analysis of charge heterogeneities in mAbs using imaged CE Electrophoresis. ,vol. 30, pp. 714- 722 ,(2009) , 10.1002/ELPS.200800636
Richard R. Rustandi, Feng Wang, Christopher Hamm, Joseph J. Cuciniello, Michelle L. Marley, Development of imaged capillary isoelectric focusing method and use of capillary zone electrophoresis in hepatitis B vaccine RECOMBIVAX HB Electrophoresis. ,vol. 35, pp. 1072- 1078 ,(2014) , 10.1002/ELPS.201300422
Stellan Hjertén, Ming-de Zhu, Adaptation of the equipment for high-performance electrophoresis to isoelectric focusing Journal of Chromatography A. ,vol. 346, pp. 265- 270 ,(1985) , 10.1016/S0021-9673(00)90512-0
Hongwei Xie, Asish Chakraborty, Joomi Ahn, Ying Qing Yu, Deepalakshmi P Dakshinamoorthy, Martin Gilar, Weibin Chen, St John Skilton, Jeffery R Mazzeo, None, Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies mAbs. ,vol. 2, pp. 379- 394 ,(2010) , 10.4161/MABS.11986
Reed J. Harris, Bruce Kabakoff, Frank D. Macchi, Felicity J. Shen, May Kwong, James D. Andya, Steven J. Shire, Nancy Bjork, Klara Totpal, Anthony B. Chen, Identification of multiple sources of charge heterogeneity in a recombinant antibody. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 752, pp. 233- 245 ,(2001) , 10.1016/S0378-4347(00)00548-X
Scott Mack, Ingrid Cruzado-Park, Jeff Chapman, Chitra Ratnayake, Gyula Vigh, A systematic study in CIEF: Defining and optimizing experimental parameters critical to method reproducibility and robustness Electrophoresis. ,vol. 30, pp. 4049- 4058 ,(2009) , 10.1002/ELPS.200800690
Dietrich Kohlheyer, Geert A. J. Besselink, Stefan Schlautmann, Richard B. M. Schasfoort, Free-flow zone electrophoresis and isoelectric focusing using a microfabricated glass device with ion permeable membranes Lab on a Chip. ,vol. 6, pp. 374- 380 ,(2006) , 10.1039/B514731J