Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium.

摘要: Zinc gets into the brain parenchyma across blood-brain and blood-cerebrospinal fluid barriers, while cadmium hardly parenchyma. Because histidine may be involved in zinc transport barrier systems, binding to was compared between understand difference permeability both metals. Sephadex G-10 gel filtration indicated that 109Cd, unlike 65Zn, does not bind histidine. When plasma incubated with 65Zn or 109Cd dialyzed physiological saline containing (0-10 mM), concentration dialysate increased increase of concentration, suggesting transfer from proteins The low affinity important for this metal. On other hand, detected presence 0.1 mM histidine, which is equal plasma, no These results suggest avid related impermeability