Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

摘要: Abstract The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2Kb chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-A2; 72% 74% HLA-B7, respectively), two stretches greater variability observed. These clusters discussed terms their possible involvement alloantigenic determinant(s) characteristic polymorphic membrane antigens.