Frequency of low-level bacteremia in children from birth to fifteen years of age.

摘要: A single blood culture inoculated with a small volume of is still frequently being used for the diagnosis bacteremia in children because continued belief by many that bacteria are usually found high concentrations pediatric patients sepsis. To determine importance both cultured and number devices required reliable detection pathogens our population, from birth to 15 years age suspected at York Hospital (a 500-bed community hospital) was into least Pediatric Isolator (Wampole Laboratories; 1.5 ml blood) or standard (10 bottle ESP anaerobic broth (Trek Diagnostic Systems; 0.5 10 blood). The use second additional aerobic bottles total recommended cultures (2 60 ml) depended on weight each patient. One hundred forty-seven were recovered 137 (3.6%) 3,829 whom culturing done. Of 121 septic episodes which concentration could be determined using Isolators, 73 (60.3%) represented low-level (≤10 CFU/ml blood), including 28 (23.1%) detected only ≤1.0 CFU/ml. 144 two more (Isolators and/or bottles) inoculated, 85 (59%) associated false-negative results one devices. 128 antibiotic therapy records complete, either started changed 88 (68.8%) following notification positive cultures. Low-level common requiring up 4 4.5% patient's appropriate, timely changes empiric therapy.