Remodeling of an acellular collagen graft into a physiologically responsive neovessel

摘要: Surgical treatment of vascular disease has become common, creating the need for a readily available, small-diameter graft. However, use synthetic materials is limited to grafts larger than 5-6 mm because frequency occlusion observed with smaller-diameter prosthetics. An alternative would be biomaterial that could used in design tissue-engineered We demonstrate (4 mm) graft constructed from collagen derived submucosa small intestine and type I bovine potential integrate into host tissue provide scaffold remodeling functional blood vessel. The results obtained using rabbit arterial bypass model have shown excellent hemostasis patency. Furthermore, within three months after implantation, were remodeled cellularized vessels exhibited physiological activity response vasoactive agents.