Chiral squaramide as multiple H-bond donor organocatalysts for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins
作者： Ze Dong , Guofu Qiu , Hai-Bing Zhou , Chune Dong
DOI: 10.1016/J.TETASY.2012.10.016
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摘要: Abstract A series of chiral bifunctional squaramide multiple H-bond donor organocatalysts have been designed and synthesized by the rational assembly privileged scaffolds indanol cinchona alkaloids. In presence 1 mol % 1a , asymmetric Michael addition reaction 1,3-dicarbonyl compounds to nitroolefins proceeded provide product in high yields (up 92%) with good ee values 96%). The additional this system plays a crucial role enhancing enantioselectivity.
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