Synthesis of structurally diverse biflavonoids

摘要: Abstract Synthetic biflavonoids are associated with interesting biological activities, yet they remain poorly explored within drug discovery. Recent years have witnessed a growing interest in synthetic approaches that can provide access to structurally novel so the usefulness of this compound class be more fully investigated. Herein, we report upon exploration strategies based around Suzuki-Miyaura cross-coupling and alcohol methylenation for synthesis two classes biflavonoids: (i) rare ‘hybrid’ derivatives containing flavonoid monomers belonging different subclasses, (ii) homodimeric compounds which linked by methylenedioxy group. Application these enabled preparation diverse collection from readily-available starting materials, thereby facilitating probing uncharted regions biologically chemical space.