Green fabricated reduced graphene oxide: evaluation of its application as nano-carrier for pH-sensitive drug delivery.
作者： Naxin Ma , Baohua Zhang , Jing Liu , Pei Zhang , Zhonghao Li
DOI: 10.1016/J.IJPHARM.2015.10.081
关键词:
摘要: A green and mild approach for the preparation of reduced graphene oxide (rGO) was proposed by using riboflavin-5'-phosphate sodium salt dihydrate as a reducing reagent stabilizer without any other reagent. The fabricated nano-rGO systematically evaluated its application nano-carrier pH-sensitive drug delivery. hemolytic toxicity test indicated as-prepared had negligible activity, which demonstrating safety in delivery system. Doxorubicin hydrochloride (DOX) model successfully attached onto surface via strong π-π stacking interaction. Compared with common carriers, obtained DOX-loaded nanohybrid exhibited characteristics high loading content, good stability, sustainable release drugs. Cytotoxicity assay results suggested such effective cytotoxicity to MCF-7 A549 cells nonspecific endocytosis mechanism. Therefore, present rGO could be candidate an ideal controlled release.
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