Spatiotemporal alterations in primary odorant representations in olfactory marker protein knockout mice.

摘要: Olfactory marker protein (OMP) is highly and selectively expressed in primary olfactory sensory neurons (OSNs) across species, but its physiological function remains unclear. Previous studies the epithelium suggest that it accelerates neural response to odorants may modulate odorant-selectivity of OSNs. Here we used a line gene-targeted mice express fluorescent exocytosis indicator synaptopHluorin place OMP compare spatiotemporal patterns odorant-evoked neurotransmitter release from OSNs adult were heterozygous for or OMP-null. We found these patterns, which constitute representation each odorant, developed more slowly during odorant presentation knockout eventually reached same magnitude as mice. In bulb, glomerulus receives synaptic input subpopulation all odor receptor thus typically respond specific subset odorants. observed mice, innervating given responded broader range than evoked larger number glomeruli. an habituation task, behaved differently wild-type exhibiting delay their onset investigate stimulus first less over repeated presentations. These results actions transduction carry through representations stimuli vivo.