A novel synthetic approach of cerium oxide nanoparticles with improved biomedical activity

摘要: Cerium oxide nanoparticles (CNPs) are novel synthetic antioxidant agents proposed for treating oxidative stress-related diseases. The synthesis of high-quality CNPs biomedical applications remains a challenging task. A major concern safe use as pharmacological is their tendency to agglomerate. Herein we present simple direct precipitation approach, exploiting ethylene glycol co-factor, synthesize at room temperature nanocrystalline sub-10 nm CNPs, followed by surface silanization approach improve nanoparticle dispersibility in biological fluids. were characterized using transmission electron microscopy (TEM) observations, X-ray diffraction (XRD) analysis, thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) dynamic light scattering (DLS) and zeta potential measurements. CNP redox activity was studied abiotic systems spin (ESR) measurements, vitro on human cell models. In-situ improved colloidal stability, comparison with non-functionalized particles, allowed the same time improving original activity, yielding thus functionalized suitable applications.