Induction of iPS cells and of cancer stem cells: the stem cell or reprogramming hypothesis of cancer?

摘要: This article as designed to examine whether the "stoichiometric" or "elite models" of origin "induced pluripotent stem" (iPS) cells fits some experiment facts from developmental biology adult stem and field cancer research. In brief, since evidence presented support stoichiometric model failed recognize factual existence organ specific cells, has not been rigorously tested. addition, demonstration a subset (MUSE cells) in normal primary vitro cultures human fibroblasts (the usual source iPS seems be cells. Moreover, carcinogenesis, "stem cell" versus "de-differentiation" "reprogramming" hypotheses were examined. Again, using role glycolysis, known associated with Warburg effect list experiments showing that (a) which have few mitochondria, metabolize via glycolysis; (b) are targets for "initiation" "immortalization" blockage differentiation apoptosis by "immortalizing viruses"; (c) Lactate dehydrogenase A (LDHA), when expressed, is glycolysis therefore, must expressed well cells; (d) p53, depleted rendered dysfunctional SV40 Large T antigen, reduction mitochondrial function mass effect. Together, these observations "cancer fields idea both cell derived organ-specific do restore switch their metabolism glucose oxidative but, rather, cases, cell, metabolizes prevented metabolizing phosphorylation.