Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.

摘要: Genetic diversity and relationships among 108 isolates of the bacterium Streptococcus pyogenes recently recovered from patients in United States with toxic-shock-like syndrome or other invasive diseases were estimated by multilocus enzyme electrophoresis. Thirty-three electrophoretic types (ETs), representing distinctive clonal genotypes, identified, but nearly half disease episodes, including more than two-thirds cases syndrome, caused strains two related clones (ET 1 ET 2). These also represented recent pathogenic European isolates. A previous report a relatively high frequency expression exotoxin was confirmed; demonstration this association both within distantly supports hypothesis that is causal factor pathogenesis disease. Near identity nucleotide sequences structural gene six five ETs diverse phylogenetic lineages interpreted as evidence has been horizontally distributed clones, presumably bacteriophage-mediated transfer.