White Paper on studying the safety of the childhood immunization schedule in the Vaccine Safety Datalink.

摘要: While the large majority of parents in U.S. vaccinate their children according to recommended immunization schedule, some have refused or delayed vaccinating, often citing safety concerns. In response public concern, Institute Medicine (IOM) evaluated existing research regarding schedule. The IOM concluded that although available evidence strongly supported currently schedule as a whole, additional observational was warranted compare health outcomes between fully vaccinated and those on alternative addition, identified Vaccine Safety Datalink (VSD) an important resource for conducting this research. Guided by findings, Centers Disease Control Prevention (CDC) commissioned White Paper assess how VSD could be used study childhood subject matter expert engagement, resulting outlines 4 stage approach identifying exposure groups undervaccinated children, presents list highest priority examine context, describes various designs statistical methods analyze it appears feasible settings such VSD, these studies will inherently complex, with all studies, need carefully address issues confounding bias. light considerations, decisions about also epidemiological potential adverse events related biological plausibility association event concern