Early-life stress induces long-term morphologic changes in primate brain.

摘要: Context Traumatic experiences in early childhood are associated with increased risk of developing stress-related disorders, which linked to structural brain abnormalities. However, it is unclear whether these volumetric changes present before disease onset or reflect the consequences progression. Objective To identify abnormalities nonhuman primate that may predict neuropsychiatric disorders human beings. Design Rhesus monkeys were divided into 2 groups at birth: a group raised their mothers and other juvenile adult animals (mother reared) 3 age-matched only (peer for first 6 months life. Anatomical images acquired male female rhesus using magnetic resonance imaging. Setting National Institutes Health Animal Center Poolesville, Maryland. Subjects Twenty-eight ( Macaca mulatta ) aged 24 30 used study. Main Outcome Measures Volumetric measures anterior cingulate cortex, medial prefrontal hippocampus, corpus callosum, cerebellar vermis compared between mother-reared (n = 15) peer-reared (n = 13). Results Compared monkeys, we found an enlarged vermis, dorsomedial dorsal cortex without any apparent differences callosum hippocampus. Conclusions Peer-rearing during infancy induces enlargement stress-sensitive regions. These be phenotype