Optimization of timing of hepatocellular phase imaging after gadoxetate disodium injection for evaluation of patients with neuroendocrine tumor.

摘要: Metastatic gastroenteropancreatic neuroendocrine neoplasms (mGEP-NEN) are indolent malignancies which undergo frequent imaging follow-up. Hepatocellular phase (HCP) MR with hepatocellular-specific contrast agent is widely used to evaluate mGEP-NEN liver metastases but commonly performed after a 20-min delay prolongs scan time. The purpose of this study was if HCP at 15 min offers comparable performance for patients undergoing routine surveillance. In IRB-approved retrospective study, we evaluated 52 who were imaged surveillance gadoxetate disodium (Eovist®)-enhanced including 15- and delayed HCP. Two readers (R1, R2), blinded timing, independently reviewed each set images in random order least 1 month apart. Readers assessed presence conspicuity metastases, subjective image quality using 5-point scales. quantified the number diameter largest lesion. Statistical analysis determine individual-reader inter-reader differences qualitative quantitative data. No observed (R1 p = 0.86, R2 p = 0.17) or lesion p = 0.56, p = 0.74) 20 min either reader. Individual-reader concordance correlation coefficient between 15 high detected (R1 = 0.9842, R2 = 0.9579) metastasis (R1 = 0.9629, R2 = 0.8859). provides similar diagnostic yield standard delay, may help reduce time costs, improve throughput patient satisfaction.