Leucemia en células del donador (LCD): un estudio prospectivo de su identificación y tratamiento

摘要: Donor-derived malignancies after allogeneic hematopoietic stem cell transplantation and solid organ are considered as rare diseases. We have prospectively searched for donor leukemia in a 12-year period, single institution, group of 106 consecutive patients allografted because leukemia. identified seven cases leukemia; six were relapsed acute lymphoblastic one paroxysmal nocturnal hemoglobinuria/aplastic anemia. These figures suggest that the real incidence has been underestimated. The with treated pediatric-inspired combined chemotherapy schedule designed de novo A complete response was obtained three out It is possible to obtain favorable responses employing chemotherapy. long-term survivors remain full chimeras not needed second transplant.