Gene-expression profiles of human tumor xenografts in nude mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839.

摘要: To date, no single or multiple molecular markers have been successful in predicting sensitivity of individual patients to anti-cancer drugs. As the nature a specific cancer is considered be defined by proteins being expressed tumor cells, systematic analysis gene-expression profiles may provide information reflecting given certain Recent progress genome technology has enabled us examine expression thousands genes experiment. We used this approach 13 xenografts human tumors implanted into nude mice for an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), ZD1839 (Iressa). identify that might associated with drug we cDNA microarray representing 23,040 analyze and identified 114 whose levels correlated significantly ZD1839. then investigated alteration response treatment four non-small cell lung (NSCLC) xenografts, which two (LC6 LC11) were sensitive other (Lu116 L27) resistant EGFR-TKI. Systematic at various time points during oral 14 days, compared corresponding untreated samples, set changed but not tumors. The data obtained here should useful on mechanism underlying clinical responses EGFR-TKIs, aid development novel therapies cancer, potentially predictive