Development and Characterization of a 3D Printed, Keratin-Based Hydrogel

摘要: Keratin, a naturally-derived polymer derived from human hair, is physiologically biodegradable, provides adequate cell support, and can self-assemble or be crosslinked to form hydrogels. Nevertheless, it has had limited use in tissue engineering been mainly used as casted scaffolds for drug growth factor delivery applications. Here, we present assess novel method the printed, sequential production of 3D keratin scaffolds. Using riboflavin-SPS-hydroquinone (initiator-catalyst-inhibitor) photosensitive solution produced constructs via UV crosslinking lithography-based printer. The hydrogels obtained have printing resolution result compressive dynamic mechanical properties, uptake swelling capacities, cytotoxicity, microstructural characteristics that are comparable superior those previously reported. keratin-based resin methodology presented potential impact future research by providing an avenue rapidly reproducibly manufacture patient-specific regenerative medicine