作者: Christopher I. Li , Janet R. Daling , Kathleen E. Malone
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摘要: Purpose: Between 1987 and 1998, breast cancer incidence rates rose 0.5%/yr in the United States. A question of potential etiologic clinical importance is whether hormone receptor status tumors also changing over time. This because may reflect different pathways useful predicting response to adjuvant therapy prognosis. Methods: Age-adjusted, age-specific by estrogen (ER) progesterone (PR) from 1992 1998 were obtained compared 11 population-based registries States that participate National Cancer Institute’s Surveillance, Epidemiology, End Results (SEER) Program. Results: From to1998, overall proportion cancers ER-positive PR-positive increased 75.4% 77.5% (P = .0002) 65.0% 67.7% < .0001), respectively, continuing trends observed before 1992. These increases limited women ...