Role of the Neutrophil Chemorepellent Soluble Dipeptidyl Peptidase IV in Decreasing Inflammation in a Murine Model of Arthritis
作者： Sarah E. Herlihy , Monica L. Brown , Darrell Pilling , Brad R. Weeks , Linda K. Myers
DOI: 10.1002/ART.39250
关键词:
摘要: Objective To determine whether an intraarticular injection of the neutrophil chemorepellent dipeptidyl peptidase IV (DPPIV; CD26) can attenuate inflammation and decrease severity arthritis in a murine model. Methods DBA/1 mice were immunized with type II collagen/Freund's complete adjuvant to produce collagen-induced (CIA). On day 25 postimmunization, recombinant human DPPIV (rhDPPIV) or phosphate buffered saline was injected intraarticularly, scores recorded 3 times per week. The hind legs both groups fixed, decalcified, paraffin embedded, sectioned. Pathologic for infiltration on scale 1–8, number neutrophils determined by morphometric cell counts. In addition, Mac-2–positive macrophages articular damage assessed using anti–Mac-2 antibodies histologic staining, respectively. Results Injection rhDPPIV reduced mean score CIA. treatment overall extent around arthritic joint periarticular tissue, also decreased macrophage infiltration. Conclusion A localized reduces disease model arthritis.
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