Protein X‐ray Crystallography in Drug Discovery
作者： Peter Nollert , Michael D. Feese , Bart L. Staker , Hidong Kim
DOI: 10.1002/9780470571224.PSE011
关键词:
摘要: Protein X-ray crystallography has affected drug discovery in (a) the identification of new targets, (b) understanding molecular target mechanisms, and (c) lead compounds. The integration protein into early process by joining it with chemical synthesis assaying become a very effective tool for optimization. This article aims to familiarize scientists crystallographic techniques their exemplified application purpose discovery. Keywords: protein x-ray crystallography; molecular mechanisms; drug discovery; drug targets
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