Histopathological and immunohistochemical characterization of canine prostate cancer.
作者： Chen-Li Lai , René van den Ham , Geert van Leenders , Jaco van der Lugt , Jan A. Mol
DOI: 10.1002/PROS.20720
关键词:
摘要: BACKGROUND. In this study we try to identify the origin of canine prostate cancer (cPC) by classifying tumors histological subtypes and relate these their combined expressional characteristics several tissue specific differentiation markers. METHODS. cPCs were examined histomorphologically immunohistochemical detection cytokeratin markers CK14, HMWCK, CK5, CK18, CK7, UPIII, PSA PSMA. RESULTS. Histopathologically, six growth patterns could be differentiated. The most frequent solid, cribriform micropapillary patterns, while sarcomatoid, small acinar/ductal, tubulo-papillary less present. Solid significantly (P = 0.027) more often seen in castrated dogs. Immunohistochemically, about half cPC cases showed expression (8/20) PSMA (10/20); 85% 60% expressed UPIII (17/20) CK7 (12/20), 13 12 CK5 respectively; all CK18. CK14 was solid than respectively. CONCLUSIONS. Canine appear aggressive a differentiated type common human cancers. Comparing those normal tissue, likely originates from collecting ducts rather peripheral acini. Given also fact that is unresponsive androgen withdrawal therapy, mostly resembles human, refractory, poorly cancer.
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