An overview of environmental and toxicological aspects of aromatic hydrocarbons. I. Benzene.

摘要: The commercial product "mixed xylenes" (a technical generally containing approximately 40% m-xylene and 20% each of o-xylene, p-xylene ethylbenzene, as well small quantities toluene) analogously to toluene is an agent major chemical occupational significance. It produced in very large extensively employed a broad spectrum applications, primarily solvent for which its use increasing "safe" replacement benzene, gasoline part the BTX component (benzene-toluene-xylene); xylenes are also frequently used rubber industry with other solvents such benzene. As individual isomers they synthesis synthetic agents, example phthalic acid, isophthalic terephthalic acid dimethylterephthalate, have applications further preparation phthalate ester plasticizers components polyester fiber, film fabricated items. There potential exposure both industrial workers production general public (via vehicle exhausts, consumer products, etc). Compared benzene toluene, much less known human health hazards, particularly chronic effects xylenes, either mixed or admixture alkylbenzenes. importance note that coal-based (e.g., xylene) been suggested be possible potent lymphocytic leukemogens, limited study relationship between leukemia exposures industry. Available animal data on carcinogenicity xylene(s) inadequate permit evaluation. Mixed currently being investigated bioassay by National Toxicology Program. In studies thus far, not found genotoxic when tested number short-term tests.