Slowing of bone loss in patients with rheumatoid arthritis by long-term high-intensity exercise: results of a randomized, controlled trial.

摘要: Objective Patients with rheumatoid arthritis (RA) are more at risk for the development of osteoporosis and osteoporotic fractures than their healthy peers. In this randomized, controlled, multicenter trial, effectiveness a 2-year high-intensity weight-bearing exercise program (the Rheumatoid-Arthritis-Patients-In-Training [RAPIT] program) on bone mineral density (BMD) was compared usual care physical therapy, modalities associated changes in BMD were determined. Methods Three hundred nine patients RA assigned to an intervention group, either RAPIT or therapy. The primary end points hip spine. examined aerobic fitness, muscle strength, and, as surrogate those effects not directly measured by program, attendance rate. Results The data 136 participants 145 who completed study analyzed. mean rate decrease BMD, but lumbar spine smaller participating when that 1.6% (95% confidence interval [95% CI] 0.8–2.5) over first year 0.5% CI 1.1–2.0) second year. change significantly independently both strength (multivariate odds ratio [OR] 1.75, 95% 1.07–2.86) fitness (OR 1.79, 1.10–2.90), 1.00, 0.99–1.00). Conclusion A long-term is effective slowing down loss hip. effect fitness.