Structural Study and Biological Evaluation of Some Novel 1,2,4-Triazole, Thiazole, and Bisthiazole Derivatives Bearing a Sulfonamide Moiety
DOI: 10.1080/10426500802417323
关键词:
摘要: The starting material 1,2,4-triazole derivative ( 3 ) was used to synthesize some novel condensed triazoles. Thus, treatment of compound with phenyl isocyanate in refluxing pyridine furnished the [1,2,4]triazolo[4,3-b][1,2,4]triazole 5 ). Also, cyclization isothiocyanate afforded [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 7 Hydrazone 9d allowed react halogenated reagents such as chloroacetone, ethyl chloroacetate, and chloroacetonitrile furnish thiazole derivatives 12 ), 13 15 respectively. In a similar manner, bishydrazone 17 prepare bisthiazoles 18 19 Some synthesized compounds were evaluated for their antibacterial activity.
sci-hub.se 参考文章(16)
Mohamed S. A. El-Gaby, Ahmed M. Sh. El-Shareif, A. G. Al-Sehemi, M. A. Zahran, U. H. El-Said, Y.A. Ammar, Some reactions with ketene dithioacetals. Part III: Novel synthesis of pyrimidine, pyrazole and pyrazolo[3,4-d]pyrimidine derivatives as antimicrobial agents Afinidad. ,vol. 61, pp. 261- 265 ,(2004)
Francis O'Grady, Lawrence Paul Garrod, Antibiotic and chemotherapy ,(1968)
B. S. HOLLA, K. N. POOJARY, B. KALLURAYA, P. V. GOWDA, Synthesis, Characterization, and Antifungal Activity of Some N-Bridged Heterocycles Derived from 3-(3-Bromo-4-methoxyphenyl)-4-amino-5- mercapto-1,2,4-triazole. ChemInform. ,vol. 28, ,(1997) , 10.1002/CHIN.199728054
M.S.A. El-Gaby, A.A. Atalla, A.M. Gaber, K.A. Abd Al-Wahab, Studies on aminopyrazoles: antibacterial activity of some novel pyrazolo[1,5-a]pyrimidines containing sulfonamido moieties Farmaco. ,vol. 55, pp. 596- 602 ,(2000) , 10.1016/S0014-827X(00)00079-3
Y. A. Ammar, M. M. Aly, A. G. Al-Sehemi, Y. A. Mohamed, M. A. Salem, M. S. A. El-Gaby, Cyanoacetanilides Intermediates in Heterocyclic Synthesis. Part 4: Preparation of Some Hitherto Unknown Thiazolidine and Bisthiazolidine Derivatives Phosphorus Sulfur and Silicon and The Related Elements. ,vol. 183, pp. 1710- 1721 ,(2008) , 10.1080/10426500701729554
Claudiu T. Supuran, Andrea Scozzafava, Bogdan C. Jurca, Marc A. Ilies, Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I European Journal of Medicinal Chemistry. ,vol. 33, pp. 83- 93 ,(1998) , 10.1016/S0223-5234(98)80033-0
Ram Lakhan, Bimal Prasad Sharma, Bishwa Nath Shukla, Synthesis and antimicrobial activity of 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines Il Farmaco. ,vol. 55, pp. 331- 337 ,(2000) , 10.1016/S0014-827X(00)00032-X
M. A. Abbady, S. Askari, M. Morgan, A. L. Ternay, J. Galloy, W. H. Watson, STRUCTURE AND BONDING IN 9-HYDROXY-1,4-DIMETHYLTHIOXANTHENIUM BIS(CARBOMETHOXY)METHYLIDE AND RELATED YLIDES Journal of Heterocyclic Chemistry. ,vol. 19, pp. 1473- 1479 ,(1982) , 10.1002/JHET.5570190644
Sh. H. Abdel-Hafez, Synthesis, Antimicrobial Activity of Some New 2-Amino-4-(4′-phenylsulfanyl-phenyl)-thiazole Derivatives and Theoretical Studies of Their Schiff's Base Phosphorus Sulfur and Silicon and The Related Elements. ,vol. 178, pp. 2563- 2579 ,(2003) , 10.1080/714040970
Y. A. Ammar, A. M. Sh. El-Sharief, Y. A. Mohamed, M. A. Salem, A. G. Al-Sehemi, M. S. A. El-Gaby, Cyanoacetanilides Intermediates in Heterocyclic Synthesis. Part 1: A Facile Synthesis of Polysubstituted and Condensed Pyridones Journal of the Chinese Chemical Society. ,vol. 51, pp. 975- 981 ,(2004) , 10.1002/JCCS.200400145