Red Blood Cell Sodium-Lithium Countertransport and Risk of Future Hypertension: The Olivetti Prospective Heart Study

摘要: An elevated red blood cell (RBC) sodium-lithium countertransport (Na-Li CT) is associated with high pressure (BP) in cross-sectional investigations; however, its value as a predictor of future hypertension, and thus cardiovascular risk, has not been defined. The present study evaluated the association between Na-Li CT risk hypertension sample 106 untreated normotensive middle-aged men participating Olivetti Prospective Heart Study southern Italy. BP, anthropometric metabolic variables, RBC were measured at baseline 1987 follow-up visit 1994 through 1995. was stable over time (r=0.85) significantly to systolic BP both visits. Of initially participants, 14 found be hypertensive 8-year examination. Eleven these hypertensives highest tertile baseline, 9 11 also had an CT. In multiple logistic regression analysis, CT, age all significant predictors hypertension. Individuals 60% developing if their high, whereas only 5% two lowest tertiles (P=0.003). valuable subsequent high-normal level for age.