Bio-Based Strategies for Producing Glycosaminoglycans and Their Oligosaccharides
作者： Zhen Kang , Zhengxiong Zhou , Yang Wang , Hao Huang , Guocheng Du
DOI: 10.1016/J.TIBTECH.2018.03.010
关键词:
摘要: Glycosaminoglycans (GAGs) and their oligosaccharides have attracted extensive attention because of wide applications in cosmetics, health, clinical treatment of, for example, thrombus, osteoarthritis, rheumatism, cancer. Compared to conventional preparation approaches, bio-based strategies producing GAGs are more promising they avoid cross-infection human animal diseases, use green production processes, can precisely control the degree sulfation molecular weight. This review summarizes recently developed GAGs, highlighting particular enzymatic, metabolic engineering, synthetic biology strategies. Directions prospects near-future research also outlined discussed.
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