Molecular Pathogenesis of Acute Pseudomonas Aeruginosa Infections

摘要: Pseudomonas aeruginosa is probably one of the best examples an “opportunistic” pathogen, i.e. that only causes disease in compromised hosts. As reviewed Chapter 1, normal individuals rarely get P. infections. Chronic aeruginosalung infections, discussed Chapters 5 and 6, are hallmark cystic fibrosis (CF). This chapter will be restricted to considering molecular pathogenesis acute These infections include (i) pneumonia hospitalized particular mechanically ventilated patients, (ii) skin sepsis patients with extensive burns, (iii) corneal wearing contact lenses, (iv) urinary tract indwelling Foley catheters, (v) bacteremia immunocompromised particularly neutropenic receiving cytotoxic therapies, (vi) post-surgical wound The magnitude costs these nosocomial enormous. For example, accounts for as much 20% hospital-acquired has a mortality rate upwards 40%, even appropriate antibiotic therapy. Likewise, secondary burn still major cause morbidity. Finally, prior institution pre-emptive therapy was leading death cancer chemotherapy.