Rapid Elimination of Blood Alcohol Using Erythrocytes: Mathematical Modeling and In Vitro Study.
作者： Yuliya G. Alexandrovich , Elena A. Kosenko , Elena I. Sinauridze , Sergey I. Obydennyi , Igor I. Kireev
DOI: 10.1155/2017/5849593
关键词:
摘要: Erythrocytes (RBCs) loaded with alcohol dehydrogenase (ADH) and aldehyde (ALD) can metabolize plasma ethanol acetaldehyde but low efficiency. We investigated the rate-limiting factors in oxidation by these enzymes into RBCs. Mathematical modeling vitro experiments on human RBCs simultaneously ADH ALD (by hypoosmotic dialysis) were performed. The simulation showed that rate of nicotinamide-adenine dinucleotide (NAD
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