Somatomedin Receptors: Structure, Function, and Regulation
作者： RON G. ROSENFELD , RAYMOND L. HINTZ
DOI: 10.1016/B978-0-12-185203-0.50015-X
关键词:
摘要: Publisher Summary This chapter discusses somatomedin receptors, and its structure, function, regulation. The somatomedins constitute a family of growth hormone-dependent peptides with anabolic mitogenic activity for variety cell lines. characterization specific receptors was hampered by the difficulties encountered in purifying preparations to meet following criteria: (1) able be iodinated high activity, (2) immunoreactive insulin-free, (3) consist single purified peptide, rather than mixture several peptides. Structural homologies between insulin insulin-like factor (IGF) explain observation that have while has These evolved from common ancestor protein, over time, their sequences, diverged accommodate metabolic demands organism. structural basis interrelationship among insulin, somatomedins, been established methods, such as affinity immunoaffinity purification membrane proteins, photoaffinity labeling, cross-linking surface receptors.
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