Genotypic and phenotypic heterogeneity in the U3R region of HIV type 1 subtype C.

摘要: Abstract Approximately 20% of all HIV-1 mother-to-child transmission (MTCT) occurs in utero (IU). In a chronic HIV infection, exists as complex swarm genetic variants, and following IU MTCT, viral genomic diversity is restricted through mechanism that remains to be described. The 5′ U3R region the long terminal repeat (LTR) contains multiple transcription factor (TF) binding sites regulates transcription. this study, we tested hypothesis sequence polymorphisms LTR are associated with MTCT. To end, used single template amplification isolate 517 sequences from maternal, placental, infant plasma derived 17 HIV-infected Malawian women: eight whose infants remained uninfected (NT) nine became infected IU. show pairwise diversities ranging 0.2% 2.3%. one participant contained two, three, or four putative NF-κB sites. Phylogenetic reconstructions i...