GABA type a receptor trafficking and the architecture of synaptic inhibition

摘要: Ubiquitous expression of GABA type A receptors (GABAA R) in the central nervous system establishes their role coordinating most aspects neural function and development. Dysregulation GABAergic neurotransmission manifests a number human health disorders conditions that certain cases can be alleviated by drugs targeting these receptors. Precise changes quantity or activity GABAA Rs localized at cell surface postsynaptic sites directly impact strength inhibition. The molecular mechanisms constituting receptor trafficking to from compartments therefore dictate efficacy R function. Here we review current understanding how traffic through biogenesis, plasma membrane transport, degradation. Emphasis is placed on discussing novel synaptic proteins, scaffolding post-translational modifications, activity-dependent confinement, neuropeptide neurosteroid mediated changes. We further highlight modern techniques currently advancing knowledge clinically relevant neurodevelopmental diseases connected dysfunction. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 238-270, 2018.